學(xué)術(shù)團(tuán)體和社會(huì)兼職:
1)學(xué)術(shù)團(tuán)體和專業(yè)協(xié)會(huì)會(huì)員:美國癌癥研究協(xié)會(huì); 美國細(xì)胞生物學(xué)協(xié)會(huì); 美國內(nèi)分泌協(xié)會(huì); 國際預(yù)防腫瘤學(xué)協(xié)會(huì); 美國分子藥理協(xié)會(huì);
美國藥理和實(shí)驗(yàn)治療協(xié)會(huì); 中國北美華人生物科學(xué)家協(xié)會(huì)。2)科學(xué)基金和學(xué)術(shù)評審委員會(huì): 美國國家衛(wèi)生研究院腫瘤研究所(NIH/NCI)科研基金評審委員;
英國腫瘤研究基金Ad Hoc評審委員; 美國國防部乳乳腺癌和前列腺癌研究基金評審委員會(huì)評審委員; 美國Susan Komen乳腺癌研究基金Ad Hoc評審委員;
中國自然科學(xué)基金醫(yī)學(xué)生物類重點(diǎn)項(xiàng)目海外評審委員; 中國教育部人事司“長江學(xué)者獎(jiǎng)勵(lì)計(jì)劃”通訊評審專家。3) 學(xué)術(shù)期刊編委和稿件評審人:浙大科學(xué) (Zhejiang
University Science,China);實(shí)用腫瘤學(xué) (Practical Oncology,China);國際肝膽胰疾病雜志 (HBPD
International,China); Cancer Research (USA); Clinical Cancer research
(USA);Molecular Cancer Therapeutics (USA); American Journal of Pathology
(USA);Biochemical Pharmacology (USA);Carcinogenesis (UK);Journal of
Histochemistry & Cytochemistry (USA);Journal of Biological Chemistry
(USA);Oncogene (UK);International Journal of Cancer (Germany);Oncology Research
(USA);International Journal of Hematology (Japan);Cancer Letter (UK);British
Pharmacology (UK);Molecular Pharmacology (USA);Journal of Pharmacy and
Pharmacology (Germany);BMC Cancer (UK);Cell Death and Differentiation
(UK);等等。
學(xué)科專長: 腫瘤生物學(xué), 分子免疫學(xué), 實(shí)驗(yàn)?zāi)[瘤治療
在研課題:
多功能納米顆粒技術(shù)與新型抗癌藥物的研究和開發(fā)
研究方向:
腫瘤生物學(xué), 激素對腫瘤生長和治療的影響,納米抗癌藥物, 腫瘤創(chuàng)新治療等
最后學(xué)歷:美國南卡羅萊納大學(xué)微生物和免疫學(xué)博士研究生
簡歷:
1978-1983 浙江醫(yī)科大學(xué)醫(yī)學(xué)系本科學(xué)生
1983-1986
浙江醫(yī)科大學(xué)公共衛(wèi)生學(xué)系碩士研究生
1986-1988 美國邁阿密大學(xué)醫(yī)學(xué)院微生物和免疫系 博士研究生
1988-1990
美國南卡羅萊納大學(xué)醫(yī)學(xué)院微生物和免疫系 博士研究生
1990-1992 美國南卡羅萊納醫(yī)科大學(xué)風(fēng)濕病和免疫學(xué) 博士后
1992-1997
美國南卡羅萊納醫(yī)科大學(xué)內(nèi)科及病理與實(shí)驗(yàn)醫(yī)學(xué)系 助理教授
1992- 美國南卡羅萊納醫(yī)科大學(xué)研究生院 博士生導(dǎo)師
1994-
美國南卡羅萊納醫(yī)科大學(xué)Hollings癌癥中心 研究員
1997-2003 美國南卡羅萊納醫(yī)科大學(xué)病理與實(shí)驗(yàn)醫(yī)學(xué)系及內(nèi)科系
副教授
2003- 美國南卡羅萊納醫(yī)科大學(xué)病理與實(shí)驗(yàn)醫(yī)學(xué)系及內(nèi)科系 教授
2004-2005
教育部春暉計(jì)劃講座教授(浙江大學(xué)醫(yī)學(xué)院)
2005- 浙江大學(xué)兼職教授,腫瘤學(xué)博士生導(dǎo)師
2008-
浙江大學(xué)求是特聘教授,博士生導(dǎo)師
業(yè)績一覽:
代表論文:
1. Fan, W,.Kasahara, M., Gutknecht, J., Klein, D., Jonkers, J., and Klein J.
Shared class II MHC polymorphisms between human and chimpanzees. Human Immunol.
26:107-121, 1989
2.Fan, W., Trifilette, R. Cooper T. and Norris, J.S. Cloning
of a μ class glutathione S-transferase gene and identification of the
glucocorticoid regulatory domains in its 5’ flanking region. Proc. Natl. Acad.
Sci. U.S.A. 89:6104-6108, 1992
3. Johnson, KR., Wang, L., Miller, MC.,
Willingham, MC. Fan, W. 5-Flurouracil interferes with paclitaxel cytotoxicity
against human solid tumor cells. Clin. Cancer Res. 3:1739-1745, 1997
4. Fan,
W., Ma, JX. And Norris, JS. Molecular cloning of TA16, a transcription
repressor, that may mediate glucocorticoid-induced growth arrest of
leiomyosarcoma cells, Mol. Endocrin. 11:1342-1352, 1997
5. Johnson, R.K.,
Young, KK, and Fan, W. Antagonistic interplay between anti-mitotic and G1/S
arresting agents in experimental combination therapy. Clin. Cancer Res.
5:2559-2565, 1999
6.Fan, W. Possible mechanisms of paclitaxel-induced
apoptosis, Biochem. Pharmacol, 57:1215-1221, 1999
7.Huang, Y. Johnson RK,
Norris, JS. and Fan, W. Nuclear factor-?B/I-?B signaling pathway may contribute
to the mediation of paclitaxel-induced apoptosis in solid tumor cells. Cancer
Res. 60:4426-4432, 2000
8.Zeng, S., Chen, YZ, Johnson, KR. and Fan, W. In
Vitro Evaluation of Sequential-dependent Combination between Docetaxel and
Doxorubicin in Human Tumor Cells. Clin. Cancer Res. 6:3766-3773,
2000
9.Huang, Y. and Fan, W. I?B kinase activation is involved in the
regulation of paclitaxel-induced apoptosis in solid tumor cells. Mol. Pharmacol.
61:105-113, 2002
10. Sui, M., Dziadyk, J., Zhu, XM, and Fan, W. Cell cycle
dependent antagonistic interactions between paclitaxel and ?-radiation in
combination therapy. Clin. Cancer Res. 10:4848-4857, 2004
11.Fan, W. Sui, M.
and Huang, Y. Glucocorticoids inhibit taxane-induced apoptosis: Mechanisms and
clinical impact. Curr. Med. Chem. 11:403-411, 2004
12.Huang, Y. Fang, Y. Wu,
J., Dziadyk, J., Zhu, XM, Sui, M., and Fan, W. Regulation of vinca
alkaloid-induced apoptosis by NF-?B/I?B pathway in human tumor cells. Mol.
Cancer Therap. 3: 271-277, 2004.
13.Sui, M. and Fan, W. Combination of
?-radiation antagonizes the cytotoxic effects of vincristine and vinblastine on
both mitotic arrest ad apoptosis. Int. Radio. Oncol. Phy. Bio. 1151-1158,
2005
14. Sui, M. Xoing X, Kraft A. and Fan, W. Combination of gemcitabine
antagonizes antitumor activity of paclitaxel through prevention of mitotic
arrest and apoptosis. Cancer Biol. Ther. 5:1015-1021, 2006
15.Sui, M., Chen,
F., Chen, Z. and Fan, W. Glucocorticoids interfere the therapeutic efficacy of
paclitaxel against human breast and ovarian xenograft tumors. Int. J. Cancer.
119-712-717, 2006
16. Sui, M. Huang, Y., Park, BH, Davidson, NE., Fan, W.
Estrogen receptor ? mediates breast cancer cells resistance to paclitaxel
through inhibition of apoptotic cell death. Cancer Res. 67: 5337-5344, 2007.
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